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The function of the enzyme acyl CoA synthetase is


A) lipolysis to release free glyceraldehyde.
B) ATP-dependent reduction prior to activation.
C) ATP-dependent activation of fatty acids using CoA.
D) Production of acetyl CoA for the TCA cycle
E) None of the answers is correct.

F) D) and E)
G) B) and E)

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The first step of β\beta oxidation is a(n) _________-linked oxidation of the fatty acyl chain.

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Describe the processes that dietary triacylglycerols must go through to be absorbed by intestines and transported in the blood stream.

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The triacylglycerols must be digested pr...

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Why is the anhydrous nature of triacylglycerols important in energy efficiency?

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Carbohydrates need to be hydrated to be ...

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Why are triacylglycerols an excellent design for energy stores?


A) They are anhydrous.
B) They are small.
C) They are highly reduced.
D) They are anhydrous, and they are small.
E) They are anhydrous, and they are highly reduced.

F) A) and C)
G) A) and E)

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E

The synthesis of fatty acids takes place in the _____________ of the cell.

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What types of reactions do cobalamin enzymes catalyze?


A) intramolecular rearrangements
B) methylations
C) reduction of ribonucleotides to deoxyribonucleotides
D) intramolecular rearrangements and reduction of ribonucleotides to deoxyribonucleotides
E) All the answers are correct.

F) B) and D)
G) All of the above

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What cholesterol derivatives facilitate the digestion of fats by incorporating dietary triacylglycerols into micelles in the intestine?


A) vitamin D
B) testosterone
C) bile acids
D) aldosterone
E) None of the answers is correct.

F) A) and B)
G) A) and C)

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How are unsaturated fatty acids degraded?

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An unsaturated fatty acid must be converted into a form that can enter the \(\beta\)-oxidation pathway. For example, in odd-numbered double bonds, the double bond must be converted from one set of carbons to another, which can then be hydrated and oxidized. This requires an isomerase that converts the cis-Δ3 double bond to a trans-Δ2 double bond. Even-numbered double bonds are converted via reductase and isomerase reactions. See text Figures 22.11 and 22.12 for further detail.

How does fatty acid oxidation differ in peroxisomes?


A) The final product is not acetyl CoA but is succinyl CoA.
B) NAD+ does not participate in the pathway.
C) The initial dehydrogenation reaction is different in that electrons are transferred to O2 to yield H2O2.
D) All oxidations use NAD+ as the oxidizing agent.
E) None of the answers is correct.

F) B) and D)
G) C) and D)

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What pathway degrades an acyl-CoA into acetyl CoA?


A) acyl transferase cycle
B) chylomicron cycle
C) glyoxylate cycle
D) carnitine cycle
E) β\beta oxidation

F) A) and B)
G) A) and C)

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Which of the following is an example of a short-lived, local-acting hormone?


A) prostaglandin
B) testosterone
C) estradiol
D) insulin
E) glucagon

F) B) and D)
G) C) and E)

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Which lipoprotein particle transports triacylglycerols from the intestine?


A) chylomicron
B) very low density lipoprotein
C) intermediate density lipoprotein
D) low density lipoprotein
E) high density lipoprotein

F) B) and D)
G) B) and C)

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Explain this statement: "Fats burn in the flame of carbohydrates."

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Acetyl CoA formed from fatty acids canno...

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The coenzyme that supplies the reductive power for fatty acid synthesis is ______________.

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How is pyrophosphate formation an important theme in biochemistry?

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The hydrolysis of inorganic pyrophosphat...

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What molecule is used to transport acetyl groups from the matrix to the cytoplasm?


A) acetyl-carnitine
B) succinyl CoA
C) oxaloacetate
D) α\alpha -ketoglutarate
E) citrate

F) A) and B)
G) B) and E)

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How many rounds of β\beta oxidation would be required for a 16-C fatty acyl chain to be degraded completely to acetyl-CoA?


A) 7
B) 8
C) 15
D) 16
E) None of the answers is correct.

F) B) and D)
G) All of the above

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What is the fate of glycerol released during lipolysis?

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The glycerol is absorbed by th...

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How is acetyl CoA carboxylase regulated globally?


A) By formation of inactive fibers
B) By the enzyme being switched off by phosphorylation and activated by dephosphorylation
C) By zymogen activation
D) By the binding of cAMP
E) None of the answers is correct.

F) C) and E)
G) B) and D)

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